Azo dyes are synthetically produced organic molecules and represent the largest group of commercial dyes. Industrial use for coloring purposes generates huge volumes of dyed effluents, which are of environmental concern. Color removal has been achieved by using microorganisms such as filamentous fungi, especially white rot fungi, and bacterial species. In this chapter, we look for a still largely unexplored microbial group – the yeasts, and based on the review of current state of the art, we discuss the potential biotechnological applications in the field of azo dyes bioremediation.