Biological Function of Prokineticins
Biological Function of Prokineticins
Secreted peptides have been implicated in diverse physiological functions. Prokineticins are a pair of regulatory peptides that signal through two highly homologous G protein-coupled receptors. Prokineticins possess a unique structural motif of five disulfide bonds and conserved N-terminal stretches. Diverse biological functions, ranging from development to adult physiology, have been attributed to prokineticins. Herein we provide an overview of current knowledge of this interesting pair of regulatory peptides.
- University of California, Davis United States
- University of California, Irvine United States
- Hebrew University of Jerusalem Israel
Neurons, Neovascularization, Pathologic, Neuropeptides, Hypothalamus, Pain, Models, Biological, Circadian Rhythm, Receptors, G-Protein-Coupled, Gastrointestinal Hormones, Animals, Humans, Perception, Vascular Endothelial Growth Factor, Endocrine-Gland-Derived, Gastrointestinal Motility, Peptides, Transcription Factors
Neurons, Neovascularization, Pathologic, Neuropeptides, Hypothalamus, Pain, Models, Biological, Circadian Rhythm, Receptors, G-Protein-Coupled, Gastrointestinal Hormones, Animals, Humans, Perception, Vascular Endothelial Growth Factor, Endocrine-Gland-Derived, Gastrointestinal Motility, Peptides, Transcription Factors
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