CT Fluoroscopy (CTF) is a technique that requires adequate radiation protection management for both patient and staff. Since the scanning plane is kept constant during the entire procedure, the same skin area is repeatedly exposed and cumulative patient skin doses can be substantial. Whereas, with conventional fluoroscopy the 2 Gy threshold dose for tissue reactions is reached after 100–200 min of fluoroscopy, it can be reached in CTF only after 3–10 min of scanning when a high tube current is applied. In contrast to diagnostic CT where the operator is protected behind the lead screen of the console, CTF procedures require the presence of the staff in the examination room. For the physician, particularly the doses to the lens of the eyes and the hands are of concern. Doses to the eyes can be anywhere in the range of 0.01–0.2 mGy per procedure. If protection is not used, there can be a substantial risk of lens opacity for procedures that require long fluoroscopy times and with several procedures per day, such as in busy department. Effective protection can be used to reduce the probability of cataract to a negligible level. Operators need to be aware of different methods of CTF guidance and the factors that determine radiation exposure of both patient and staff. This becomes more important as the spectrum of CTF procedures might expand to more complex procedures that may require longer fluoroscopy times.