Wound frequently complicates the quality of life of these patients. Despite the significant number of publications made on the subject are very few randomized trials published. It follows that the available evidence in the literature is of low level. The application of NPWT in treatment of the wound is very heterogeneous: negative-pressure wound therapy for treating surgical wound healing by secondary intention; negative-pressure wound therapy for treating leg ulcers; and negative-pressure wound therapy for treating pressure ulcers. Randomized controlled trials (RCTs) were identified through a systematic review of published literature (full article, thesis, or abstract). The types of interventions were NPWT in experimental group versus SWHSI in control group (surgical debridement, enzyme or chemical necrosectomy). We identified nine publications that fulfilled the inclusion criteria: six publications reported data about pressure ulcers, two publications reported data about the surgical wound healing by secondary intention (SWHSI), and one publication reported data about the leg ulcers. Despite the considerable amount of studies on the subject, the number of RCTs is modest. Patient characteristics, treatment, and outcome analyzed are very different. For these reasons it’s impossible to perform a meta-analysis. Our update systematic reviews of the literature did not lead to any new conclusions. Our result is still a result of the bias of publications.