Continuous GPS monitoring on global and regional scales has become an essential component of geophysical and meteorological infrastructure for studying fundamental Earth processes that drive natural hazards, weather, and climate. The NASA-funded “Solid Earth Science ESDR System (SESES)” project provides long-term Earth Science Data Records (ESDRs), the result of a combined solution of independent GPS analyses by the Jet Propulsion Laboratory and Scripps Institution of Oceanography using a common source of metadata archived at the Scripps Orbit and Permanent Array Center. The project has now produced up to twenty-two years of consistent, calibrated and validated ESDR products for over 3,200 GPS stations in western North America, other plate boundaries, and global networks. We describe the methodology to estimate a single set of time series with 24-h resolution of station displacements in north, east and vertical components. This is followed by a time series analysis for velocities, coseismic offsets, postseismic deformation, seasonal signals and nuisance offsets, primarily due to GPS antenna changes. Realistic one-sigma velocity are on the order of 0.03–0.05 mm/year in horizontal components and 0.1–0.3 mm/year in the vertical based on time series of 10–20 year duration. We present examples of time series that are well modeled by this parameterization and of time series that exhibit residual transient motions exhibiting episodic tremor and slip (ETS) processes. The project also catalogs seismic displacement and velocity waveforms estimated for a set of historical earthquakes in Japan and the U.S. through a seismogeodetic combination of GPS and collocated strong-motion accelerometers.