The radial basis function (RBF) neural networks have been widely used for approximation and learning due to its structural simplicity. However, there exist two difficulties in using traditional RBF networks: How to select the optimal number of intermediate layer nodes and centers of these nodes? This paper proposes a novel ART2/RBF hybrid neural networks to solve the two problems. Using the ART2 neural networks to select the optimal number of intermediate layer nodes and centers of these nodes at the same time and further get the RBF network model. Comparing with the traditional RBF networks, the ART2/RBF networks have the optimal number of intermediate layer nodes , optimal centers of these nodes and less error.