When quantitative analysis or quantitative chemical synthesis is performed using a micrototal analysis system (microTAS), the technologies for precise metering, transporting, and mixing of droplets are required. In this chapter, several technologies for the handling of droplets are described. For metering, dispensing and transporting of droplets, pneumatic and electrokinetic forces are used. Separation of cells and particles is also performed by electrical operation. Other handling technique, such as ultrasonic or centrifugal force applications, are also reviewed. Robotic synthesis devices or high throughput screening devices are promising applications for these technologies.