Identification of the bZIP and Rta Homologues in the Genome of Rhesus Monkey Rhadinovirus
Copyright policy )Identification of the bZIP and Rta Homologues in the Genome of Rhesus Monkey Rhadinovirus
Rhesus monkey rhadinovirus (RRV) is a gamma2-herpesvirus identified from the peripheral blood mononuclear cells of rhesus macaques (Macaca mulatta). Serologic studies suggested that the infections of RRV are prevalent among rhesus monkeys. RRV can be efficiently propagated and grows to a high titer in cultured rhesus monkey fibroblasts, thus providing a valuable model to study the rhadinovirus replication. By comparative genomic studies, here we describe the identification of two potential transcriptional factors encoded by RRV, designated as R-Rta and R-bZIP. Initial functional characterization of these products suggested that R-Rta is a potent transcriptional activator and R-bZIP forms homodimers in vivo. Viral homologues of R-Rta and R-bZIP, previously identified from other rhadinoviruses, have been implicated in serving as molecular switches in lytic replication.
- University of California, Davis United States
- University of California, San Francisco United States
- University of California United States
- Harvard Medical School United States
- University of California United States
Transcriptional Activation, Rhadinovirus, RNA splicing, Molecular Sequence Data, RRV, Receptors, Cell Surface, KSHV, Genome, Viral, Virology, bZIP, rhesus monkey rhadinovirus, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Cells, Cultured, Leucine Zippers, Sequence Homology, Amino Acid, Heterotrimeric GTP-Binding Proteins, Macaca mulatta, DNA-Binding Proteins, Rta, RNA, Viral, Sequence Alignment, Transcription Factors
Transcriptional Activation, Rhadinovirus, RNA splicing, Molecular Sequence Data, RRV, Receptors, Cell Surface, KSHV, Genome, Viral, Virology, bZIP, rhesus monkey rhadinovirus, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Cells, Cultured, Leucine Zippers, Sequence Homology, Amino Acid, Heterotrimeric GTP-Binding Proteins, Macaca mulatta, DNA-Binding Proteins, Rta, RNA, Viral, Sequence Alignment, Transcription Factors
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