Dugbe Nairovirus S Segment: Correction of Published Sequence and Comparison of Five Isolates
Copyright policy )Dugbe Nairovirus S Segment: Correction of Published Sequence and Comparison of Five Isolates
The sequence of the S (small) RNA segment of the ArD 44313 isolate of Dugbe nairovirus (DUG) has been redetermined, and a number of apparent errors in the previously reported sequence (V. K. Ward, A. C. Marriott, A. A. El-Ghorr, and P. A. Nuttall, 1990, Virology 175, 518-524) were revealed. Our results indicate that the S RNA is 1716 nucleotides (nt) in length and contains one large open reading frame spanning 1449 nt. This can encode a 483 amino acid polypeptide, M(r) 53.9 kDa, corresponding to the viral nucleocapsid protein N. The DUG N protein is thus similar in length to the N proteins of Hazara (HAZ) and Crimean-Congo haemorrhagic fever (CCHF) nairoviruses, which are 485 and 482 amino acids in length, respectively. S segment RNA sequences were also determined for DUG isolates IbAr 1792, IbH 11480, ArD 16095, and KT 281/75; only the KT 281/75 sequence differed markedly from that of ArD 44313. Phylogenetic trees were constructed for these nairovirus S segment sequences.
- University of Glasgow United Kingdom
- Institute of Biomedical Science United Kingdom
Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, family Bunyaviridae, phylogeny, Cell Line, S segment sequences, Mice, Virology, Cricetinae, Nairovirus, Sequence Homology, Nucleic Acid, DNA, Viral, Animals, RNA, Viral, Amino Acid Sequence, Dugbe nairovirus, Phylogeny
Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, family Bunyaviridae, phylogeny, Cell Line, S segment sequences, Mice, Virology, Cricetinae, Nairovirus, Sequence Homology, Nucleic Acid, DNA, Viral, Animals, RNA, Viral, Amino Acid Sequence, Dugbe nairovirus, Phylogeny
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