Role of Cbfa1 in osteoblast differentiation and function
Copyright policy )Role of Cbfa1 in osteoblast differentiation and function
Among the multiple cell lineages whose differentiation is affected by a runt-related gene the osteoblast is a relative newcomer. Molecular biology, developmental biology and mouse and human genetic studies have demonstrated that Cbfa1 is a critical regulator of osteoblast differentiation in vertebrates. Cbfa1 is not only a differentiation factor but also a regulator of bone formation by differentiated osteoblasts beyond development. Thus, Cbfa1 controls osteogenesis at multiple stages.
- Baylor College of Medicine United States
Osteoblasts, Transcription, Genetic, Gene Expression Regulation, Developmental, Cell Differentiation, Core Binding Factor Alpha 1 Subunit, Neoplasm Proteins, Osteogenesis, Animals, Humans, Amino Acid Sequence, Transcription Factors
Osteoblasts, Transcription, Genetic, Gene Expression Regulation, Developmental, Cell Differentiation, Core Binding Factor Alpha 1 Subunit, Neoplasm Proteins, Osteogenesis, Animals, Humans, Amino Acid Sequence, Transcription Factors
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