Protease-activated Receptor-2 (PAR2) in the Airways
Copyright policy )Protease-activated Receptor-2 (PAR2) in the Airways
Protease-activated receptors (PARs) act as sensors for active extracellular serine proteases. Since serine proteases like mast cell tryptase are associated with inflammatory processes, PARs may represent novel pharmacological targets in airway diseases like asthma and chronic obstructive pulmonary disease. However, our present understanding of the physiological roles of PARs is in its infancy. In this review we highlight evidence for the involvement of PARs in airway disease and propose that these novel receptors may play mainly protective roles.
- University of Melbourne Australia
Inflammation, Respiratory Tract Diseases, Serine Endopeptidases, Asthma, Epithelium, Humans, Receptor, PAR-2, Receptors, Thrombin, Trypsin, Tryptases, Lung Diseases, Obstructive, Lung
Inflammation, Respiratory Tract Diseases, Serine Endopeptidases, Asthma, Epithelium, Humans, Receptor, PAR-2, Receptors, Thrombin, Trypsin, Tryptases, Lung Diseases, Obstructive, Lung
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).116 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!