The Staphylococcal Insertion Sequence IS257Is Active
Copyright policy )The Staphylococcal Insertion Sequence IS257Is Active
The plasmid pJ3356 confers high-level mupirocin resistance on a strain of Staphylococcus aureus isolated from a hospital. The plasmid also carries two copies of IS257. Recombination of an IS257-containing plasmid conferring erythromycin resistance, pOX7-IS, into either of the IS257s of pJ3356 has been observed. The co-integration of pJ3356 and a small plasmid, pOX7, is also reported and involves duplication of one of the IS257s from pJ3356 together with 8 bp of pOX7 at the site of integration. Thus IS257 has been shown to be an active mobile genetic element.
- St Thomas' Hospital United Kingdom
- Guy's and St Thomas' NHS Foundation Trust United Kingdom
- University of Oxford United Kingdom
DNA, Bacterial, Staphylococcus aureus, Base Sequence, Molecular Sequence Data, DNA Transposable Elements, Gene Expression Regulation, Bacterial, DNA Primers, Plasmids
DNA, Bacterial, Staphylococcus aureus, Base Sequence, Molecular Sequence Data, DNA Transposable Elements, Gene Expression Regulation, Bacterial, DNA Primers, Plasmids
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