Molecular mechanisms of immunomodulatory activity of glucocorticoids

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2002 Italy English Publisher:Elsevier BVJournal:Pharmacological Research, volume 45, pages 361-368 (issn: 1043-6618,

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Authors: RICCARDI, Carlo; BRUSCOLI, STEFANO; MIGLIORATI, Graziella;

doi: 10.1006/phrs.2002.0969

pmid: 12123623

handle: 11391/150905

Molecular mechanisms of immunomodulatory activity of glucocorticoids

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Abstract

The development and function of cells in the immune system are regulated by many intrinsic and extrinsic factors. One class of molecule that affects immune cells belongs to the neuroendocrine system and the best-studied mediators in this category are glucocorticoids. These are small lypophilic molecules that participate in a wide number of normal and pathologic processes. This paper concentrates on their physiologic and pharmacologic effects on the immune response.

Country

Italy

Related Organizations

University of Perugia
Italy

Keywords

Receptors, Glucocorticoid, Adjuvants, Immunologic, glucocorticoids; immunomodulation, Cell Survival, T-Lymphocytes, Animals, Cytokines, Humans, Glucocorticoids

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