Leptospira interrogans binds to the CR3 receptor on mammalian cells
Copyright policy )Leptospira interrogans binds to the CR3 receptor on mammalian cells
Pathogenic leptospires adhere to phagocytes even in the absence of specific antibodies; we demonstrate that the CR3 integrin (known as Mac-1 or CD11b/CD18 receptor), expressed on neutrophils and CHO Mac-1 transfected cells, recognizes and binds leptospires. The I-domain of the molecule seems to be involved in the recognition and data suggest that this occurs via fibronectin absorbed at the Leptospira surface. On the other hand, since N-acetyl-D-glucosamine does not behave as antagonist of the binding, the lectin-like domain of the receptor is not involved in the recognition.
Neutrophils, Cricetinae, Animals, Humans, Macrophage-1 Antigen, CHO Cells, Leptospira interrogans, Transfection, Cells, Cultured
Neutrophils, Cricetinae, Animals, Humans, Macrophage-1 Antigen, CHO Cells, Leptospira interrogans, Transfection, Cells, Cultured
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