Abstract A calorimetric technique is described for measuring the enthalpy of dissociation liberated from solid hydrates. In this study, the enthalpies of dissociation were determined at T = 273.65 K andp = 0.1 MPa for simple and mixed hydrates of carbon dioxide, nitrogen, (carbon dioxide + nitrogen), and (carbon dioxide + nitrogen + tetrahydrofuran) using an isothermal microcalorimeter. The addition of tetrahydrofuran (THF) promoted hydrate stability and increased the number of guest molecules encaged in the small and large cavities of the hydrate lattice, resulting in lower enthalpy of dissociation, compared with structure II hydrate. The composition ratio of guest molecules did not affect the enthalpy of dissociation, which was found to be nearly constant for the same mixture.