Structural Basis of Molecular Mimicry
Copyright policy )Structural Basis of Molecular Mimicry
Infectious agents are thought to play an important role in the development of autoimmune diseases. Sequence similarity between infectious agents and self-proteins (molecular mimicry) has been proposed as a mechanism for the induction of autoimmunity [1]. However, it has been difficult to identify microbial peptides that activate autoreactive T cells using conventional sequence alignments. This chapter reviews progress made in the identification of such microbial peptides based on the analysis of structural features that are important for TCR recognition of MHC-bound peptides [2].
- Harvard University United States
- Dana-Farber Cancer Institute United States
Multiple Sclerosis, T-Lymphocytes, Molecular Mimicry, Molecular Sequence Data, Histocompatibility Antigens Class II, Receptors, Antigen, T-Cell, Autoimmunity, Myelin Basic Protein, Cross Reactions, Crystallography, X-Ray, Lymphocyte Activation, Peptide Fragments, Autoimmune Diseases, Structure-Activity Relationship, Viral Proteins, Humans, Amino Acid Sequence, HLA-DR2 Antigen
Multiple Sclerosis, T-Lymphocytes, Molecular Mimicry, Molecular Sequence Data, Histocompatibility Antigens Class II, Receptors, Antigen, T-Cell, Autoimmunity, Myelin Basic Protein, Cross Reactions, Crystallography, X-Ray, Lymphocyte Activation, Peptide Fragments, Autoimmune Diseases, Structure-Activity Relationship, Viral Proteins, Humans, Amino Acid Sequence, HLA-DR2 Antigen
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