JAK3 Maps to Human Chromosome 19p12 within a Cluster of Proto-oncogenes and Transcription Factors

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1997 English Publisher:Elsevier BVJournal:Genomics, volume 43, pages 109-111 (issn: 0888-7543,

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Authors: S M, Hoffman; K S, Lai; J, Tomfohrde; A, Bowcock; L A, Gordon; H W, Mohrenweiser;

doi: 10.1006/geno.1997.4792

pmid: 9226382

JAK3 Maps to Human Chromosome 19p12 within a Cluster of Proto-oncogenes and Transcription Factors

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Abstract

The gene for the most recently discoverd member of a family of cytoplasmic tyrosine kinases, JAK3, was mapped to human chromosome 19p12 using polymerase chain reaction. JAK3 plays a role in the interleukin (IL)-2 signaling pathway that regulates T and B lymphocyte development and proliferation. 20 refs., 1 fig.

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Keywords

Genetic Markers, Multigene Family, Proto-Oncogenes, Chromosome Mapping, Humans, Janus Kinase 3, Protein-Tyrosine Kinases, Cosmids, Chromosomes, Human, Pair 19, Transcription Factors

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