Circadian Aqueous Flow Mediated by β-arrestin Induced Homologous Desensitization
Copyright policy )Circadian Aqueous Flow Mediated by β-arrestin Induced Homologous Desensitization
It was hypothesized that homologous desensitization regulates signal transduction from the beta-adrenergic receptor in the ocular ciliary epithelium to affect the circadian rhythm of aqueous humor secretion. beta-arrestin-1 was cloned from the rabbit ciliary epithelium, and the full length cDNA used as a probe for Northern blot analysis to examine the diurnal expression of beta-arrestin mRNA. Protein expression of beta-arrestin-1 at intervals during the circadian cycle of aqueous secretion showed a decrease in beta-arrestin expression when maximal activation of the beta-adrenergic receptor is known to increase secretion. Diurnal expression of beta-arrestin suggests that homologous desensitization can regulate the circadian rhythm of aqueous flow.
- Yale University United States
- Emory University United States
Male, Arrestin, Blotting, Western, Ciliary Body, Molecular Sequence Data, Blotting, Northern, Epithelium, Circadian Rhythm, Aqueous Humor, Gene Expression Regulation, Species Specificity, Animals, Amino Acid Sequence, RNA, Messenger, Rabbits, Fluorescent Antibody Technique, Indirect
Male, Arrestin, Blotting, Western, Ciliary Body, Molecular Sequence Data, Blotting, Northern, Epithelium, Circadian Rhythm, Aqueous Humor, Gene Expression Regulation, Species Specificity, Animals, Amino Acid Sequence, RNA, Messenger, Rabbits, Fluorescent Antibody Technique, Indirect
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