The Tumor Suppressor Protein p16INK4a
Copyright policy )The Tumor Suppressor Protein p16INK4a
The tumor suppressor protein p16INK4a (inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16INK4a gene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer. p16INK4a is part of a cell-cycle regulatory pathway that converges in the tumor suppressor protein Rb. The mechanisms that regulate p16INK4a are starting to be characterized.
Mammals, Genes, p16, Cell Cycle, Proteins, Models, Biological, Retinoblastoma Protein, Cyclin-Dependent Kinases, Neoplasms, Tumor Suppressor Protein p14ARF, Animals, Humans, Alleles, Cyclin-Dependent Kinase Inhibitor p16
Mammals, Genes, p16, Cell Cycle, Proteins, Models, Biological, Retinoblastoma Protein, Cyclin-Dependent Kinases, Neoplasms, Tumor Suppressor Protein p14ARF, Animals, Humans, Alleles, Cyclin-Dependent Kinase Inhibitor p16
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