DISCORDANCE BETWEEN THE EFFECT OF MODULATORS OF CALCIUM ON STAUROSPORINE‐INDUCED APOPTOSIS AND STAUROSPORINE‐INDUCED ACTIN DEGRADATION

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2002 English Publisher:WileyJournal:Cell Biology International, volume 26, pages 433-440 (issn: 1065-6995, eissn: 1095-8355,

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Authors: Simon W, Rabkin; Jennifer Y, Kong;

doi: 10.1006/cbir.2002.0876

pmid: 12095229

DISCORDANCE BETWEEN THE EFFECT OF MODULATORS OF CALCIUM ON STAUROSPORINE‐INDUCED APOPTOSIS AND STAUROSPORINE‐INDUCED ACTIN DEGRADATION

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Abstract

AbstractStaurosporine produced DNA fragmentation characteristic of apoptosis and a dramatic alteration of cell structure that include alterations of cytoskeletal actin and cytoplasmic condensation with vacuolization. These changes were not induced by chelerythrine, a more specific PKC inhibitor than staurosporine. The calcium chelator, BAPTA, significantly reduced staurosporine‐induced DNA fragmentation but did not affect staurosporine‐induced changes in cytoskeletal actin. These data suggest that DNA fragmentation and actin degradation in apoptosis, induced by staurosporine, are under different regulatory control by calcium.

Related Organizations

University of British Columbia
Canada

Keywords

Heart Ventricles, Apoptosis, Chick Embryo, DNA Fragmentation, Staurosporine, Actins, Animals, Calcium, Egtazic Acid, Cells, Cultured, Chelating Agents

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