EFFECTS OF INSULIN‐LIKE GROWTH FACTOR‐BINDING PROTEIN 2 AND AN IGF‐TYPE I RECEPTOR‐BLOCKING ANTIBODY ON APOPTOSIS IN HUMAN TERATOCARCINOMA CELLS IN VITRO
Copyright policy )EFFECTS OF INSULIN‐LIKE GROWTH FACTOR‐BINDING PROTEIN 2 AND AN IGF‐TYPE I RECEPTOR‐BLOCKING ANTIBODY ON APOPTOSIS IN HUMAN TERATOCARCINOMA CELLS IN VITRO
Human teratocarcinoma cells (Tera‐2) deprived of serum undergo programmed cell death which can be counteracted by simultaneous addition of IGF‐I or IGF‐II. This protective effect of IGFs was specific in the sense that both addition of IGF‐binding protein‐2, and blocking of the IGF‐type I receptor by a specific antibody, both resulted in an increased apoptotic rate.
Teratocarcinoma, Time Factors, Dose-Response Relationship, Drug, Apoptosis, Cell Count, Antibodies, Receptor, IGF Type 1, Insulin-Like Growth Factor II, Tumor Cells, Cultured, Humans, Insulin-Like Growth Factor I, Cell Division
Teratocarcinoma, Time Factors, Dose-Response Relationship, Drug, Apoptosis, Cell Count, Antibodies, Receptor, IGF Type 1, Insulin-Like Growth Factor II, Tumor Cells, Cultured, Humans, Insulin-Like Growth Factor I, Cell Division
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