Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1
Copyright policy )Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1
ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the hypoxia-mediated inducibility. This region contained a hypoxia responsive element-like sequence, and HIF-1 bound to it under the hypoxic condition. Double-stranded synthetic oligonucleotides of this sequence as a decoy inhibited the hypoxia-mediated inducibility. These results indicate that hypoxia induces ETS-1 via the activity of HIF-1.
- Tohoku University Japan
Binding Sites, Base Sequence, Proto-Oncogene Proteins c-ets, Molecular Sequence Data, Nuclear Proteins, DNA, Neoplasm, Hypoxia-Inducible Factor 1, alpha Subunit, Cell Hypoxia, DNA-Binding Proteins, Proto-Oncogene Protein c-ets-1, Proto-Oncogene Proteins, Tumor Cells, Cultured, Humans, Hypoxia-Inducible Factor 1, RNA, Messenger, RNA, Neoplasm, Luciferases, Promoter Regions, Genetic, Sequence Deletion, Transcription Factors
Binding Sites, Base Sequence, Proto-Oncogene Proteins c-ets, Molecular Sequence Data, Nuclear Proteins, DNA, Neoplasm, Hypoxia-Inducible Factor 1, alpha Subunit, Cell Hypoxia, DNA-Binding Proteins, Proto-Oncogene Protein c-ets-1, Proto-Oncogene Proteins, Tumor Cells, Cultured, Humans, Hypoxia-Inducible Factor 1, RNA, Messenger, RNA, Neoplasm, Luciferases, Promoter Regions, Genetic, Sequence Deletion, Transcription Factors
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