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I.R. "OLYMPIAS"
Article . 2000
Data sources: I.R. "OLYMPIAS"
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Biochemical and Biophysical Research Communications
Article . 2000 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
Biochemical and Biophysical Research Communications
Article . 2000
Data sources: Europe PubMed Central
https://dx.doi.org/10.1006/bbr...
Article
Data sources: Microsoft Academic Graph
University of Freiburg: FreiDok
Article . 2000
Data sources: Bielefeld Academic Search Engine (BASE)
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N-myc Down-Regulates Activin A

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2000 Greece, Germany English Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 274, pages 405-409 (issn: 0006-291X, Copyright policy )
Authors: Breit, Stephen; Rößler, Jochen; Fotsis, Theodore; Schweigerer, Lothar;

doi: 10.1006/bbrc.2000.3147

pmid: 10913351

N-myc Down-Regulates Activin A

Abstract

N-myc oncogene amplification is frequent in human neuroblastoma and predicts poor prognosis, but the molecular consequences have remained obscure. We report here that enhanced N-myc expression correlates with low or undetectable expression of activin A, but not other closely related members of the transforming growth factor-beta superfamily. N-myc interacts with the activin A promoter, eventually inducing down-regulation of activin A mRNA and protein. This study demonstrates for the first time N-myc-induced down-regulation of a gene implicated in signal transduction. Down-regulation of activin A could deprive neuroblastomas from a signal with growth-inhibitory activities toward the tumor and its stroma and thereby permit neuroblastoma progression.

Countries
Greece, Germany
Related Organizations
Keywords

Retinoblastoma/*metabolism/pathology, Transcription, Genetic, Molecular Sequence Data, Down-Regulation, Peptides/metabolism, Transfection, Kidney, Transcription, Genetic/drug effects, Cell Line, Proto-Oncogene Proteins c-myc, *Prostatic Secretory Proteins, Neuroblastoma, Inhibins/genetics/*metabolism, Proto-Oncogene Proteins c-myc/genetics/*metabolism/pharmacology, Genes, Reporter, Sequence Analysis, Protein, Neuroblastoma/*metabolism/pathology, Humans, Inhibins, Amino Acid Sequence, Promoter Regions, Genetic, Promoter Regions, Genetic/drug effects, Kidney/cytology/*metabolism, Down-Regulation/drug effects/*physiology, Gene Amplification, Retinoblastoma, Prostatic Secretory Proteins, Culture Media, Conditioned/metabolism, Activins, Clone Cells, Culture Media, Conditioned, Transforming Growth Factor beta/biosynthesis, Peptides

  • BIP!
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 9
    popularity
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    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Average
Average
Average
Green