Identification of Viral Macrophage Inflammatory Protein (vMIP)-II as a Ligand for GPR5/XCR1
Copyright policy )Identification of Viral Macrophage Inflammatory Protein (vMIP)-II as a Ligand for GPR5/XCR1
Lymphotactin is unique among chemokines in that it contains only two of four conserved cysteines and may possess a structure less constrained than other chemokines. The viral chemokine vMIP-II, which presumably has a structure similar to that of CC chemokines has been shown to inhibit many chemokine receptors, but its activity at GPR5/XCR1 has not been described. Interestingly, vMIP-II (but not vMIP-I) was found to be a potent antagonist of lymphotactin activity at GPR5/XCR1, extending the range of chemokine classes that this viral protein is known to inhibit to include the C class chemokine. In addition, we have extended previous analyses of GPR5/XCR1 expression and show that this receptor is expressed in leukocyte cells previously shown to be responsive to lymphotactin.
- Schering-Plough United States
Lymphokines, Base Sequence, Sialoglycoproteins, Gene Expression, Membrane Proteins, Receptors, Cell Surface, Macrophage Inflammatory Proteins, Ligands, Recombinant Proteins, Cell Line, Chemokines, C, Receptors, G-Protein-Coupled, Mice, Animals, Humans, Calcium, Tissue Distribution, Chemokines, Cloning, Molecular, DNA Primers
Lymphokines, Base Sequence, Sialoglycoproteins, Gene Expression, Membrane Proteins, Receptors, Cell Surface, Macrophage Inflammatory Proteins, Ligands, Recombinant Proteins, Cell Line, Chemokines, C, Receptors, G-Protein-Coupled, Mice, Animals, Humans, Calcium, Tissue Distribution, Chemokines, Cloning, Molecular, DNA Primers
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