Interferon-γ Mediates Gene Expression of IL-18 Binding Protein in Nonleukocytic Cells
Copyright policy )Interferon-γ Mediates Gene Expression of IL-18 Binding Protein in Nonleukocytic Cells
Interleukin-18 (IL-18) binding protein is a soluble decoy receptor for IL-18 which efficiently antagonizes biological functions of IL-18 in vitro and in vivo. Since regulation of IL-18 activity likely contributes to the pathogenesis of inflammatory diseases as well as malignancies, we investigated gene expression of IL-18 binding protein (IL-18BP) in different human cell systems, namely in the keratinocyte cell line HaCaT, in the colon carcinoma cell line DLD-1, and in primary renal mesangial cells. In unstimulated cells only minute amounts of mRNA coding for IL-18 binding protein were detectable. However, in all three cell types gene expression was markedly upregulated by interferon-gamma (IFN-gamma). IL-18 is recognized as a pivotal mediator of IFN-gamma production. Therefore, the present data imply that activity of IL-18 is modulated by a negative feedback mechanism which is mediated by IFN-gamma-induced IL-18 binding protein.
- Goethe University Frankfurt Germany
Keratinocytes, Transcription, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-18, Cell Line, Glomerular Mesangium, Interferon-gamma, Gene Expression Regulation, Colonic Neoplasms, Tumor Cells, Cultured, Humans, Intercellular Signaling Peptides and Proteins, Cells, Cultured, Glycoproteins, Interleukin-1
Keratinocytes, Transcription, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-18, Cell Line, Glomerular Mesangium, Interferon-gamma, Gene Expression Regulation, Colonic Neoplasms, Tumor Cells, Cultured, Humans, Intercellular Signaling Peptides and Proteins, Cells, Cultured, Glycoproteins, Interleukin-1
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