Phosphorylation of Mitochondrial Telomere Binding Protein ofCandida parapsilosisby Camp-Dependent Protein Kinase
Copyright policy )Phosphorylation of Mitochondrial Telomere Binding Protein ofCandida parapsilosisby Camp-Dependent Protein Kinase
Mitochondrial telomere-binding protein (mtTBP) of Candida parapsilosis binds with high affinity to 5' single-stranded overhang of the linear mitochondrial DNA of this yeast (Tomáska, L'., Nosek, J., and Fukuhara, H. (1997) J. Biol. Chem. 272, 3049-3056). Here it is reported that mtTBP is phosphorylated by catalytic subunit of cAMP-dependent protein kinase in vitro. Phosphorylated mtTBP has dramatically reduced ability to bind telomeric oligonucleotide in the gel-mobility retardation assay without affecting the oligomerization of mtTBP in vitro. MtTBP is one of the few mitochondrial proteins and the first mitochondrial single-strand DNA binding proteins that was demonstrated to serve as a substrate for cAMP-dependent protein kinase.
- Comenius University Slovakia
DNA, Single-Stranded, Telomere, Cyclic AMP-Dependent Protein Kinases, DNA, Mitochondrial, Mitochondria, DNA-Binding Proteins, Fungal Proteins, Cross-Linking Reagents, Glutaral, Electrophoresis, Polyacrylamide Gel, Phosphorylation, Candida
DNA, Single-Stranded, Telomere, Cyclic AMP-Dependent Protein Kinases, DNA, Mitochondrial, Mitochondria, DNA-Binding Proteins, Fungal Proteins, Cross-Linking Reagents, Glutaral, Electrophoresis, Polyacrylamide Gel, Phosphorylation, Candida
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).11 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!