Peroxynitrite Scavenging by Flavonoids

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1997 Netherlands English Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 236, pages 591-593 (issn: 0006-291X,

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Authors: Haenen, G.R.M.M.; Paquay, J.B.G.; Korthouwer, R.E.M.; Bast, A.;

doi: 10.1006/bbrc.1997.7016

pmid: 9245694

handle: 1871/24912

Peroxynitrite Scavenging by Flavonoids

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Abstract

The peroxynitrite scavenging activity of a series of structurally related flavonoids was tested. It was found that flavonoids are excellent scavengers of peroxynitrite. Compared to the known peroxynitrite scavenger ebselen, the most active flavonoids proved to be 10 times more effective. Indications were found that the catechol group (ring B) and the hydroxyl group at position 3 give the highest contribution to the peroxynitrite scavenging effect. The peroxynitrite scavenging is discussed in relation to the beneficial effect of flavonoid intake on the incidence of coronary heart disease.

Country

Netherlands

Related Organizations

Vrije Universiteit Amsterdam
Netherlands

Keywords

Flavonoids, Structure-Activity Relationship, Nitrates, SDG 3 - Good Health and Well-being, Molecular Structure, Rutin, Quercetin, Free Radical Scavengers, Hydroxylation

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