Inhibition of Human Leukocyte Proteinase 3 by a Novel Recombinant Serine Proteinase Inhibitor (LEX032)
Copyright policy )Inhibition of Human Leukocyte Proteinase 3 by a Novel Recombinant Serine Proteinase Inhibitor (LEX032)
The interaction of a bioengineered serpin (LEX032) with human leukocyte proteinase 3 (PR 3) has been investigated. LEX032 was found to be a time-dependent inhibitor of PR 3, forming a highly-stable enzyme-inhibitor complex (Ki 12 nM).
- Wichita State University United States
Serine Proteinase Inhibitors, Myeloblastin, 610, In Vitro Techniques, Research Support, Binding Sites/genetics, Serine Endopeptidases/metabolism, Serpins/genetics, Leukocytes, Recombinant Proteins/genetics, Humans, Amino Acid Sequence, Recombinant Proteins/pharmacology, Non-U.S. Gov't, Serpins, Serine Proteinase Inhibitors/pharmacology, Binding Sites, Serine Endopeptidases, Serine Proteinase Inhibitors/genetics, Leukocytes/enzymology, Recombinant Proteins, In Vitro, Serpins/pharmacology, Kinetics
Serine Proteinase Inhibitors, Myeloblastin, 610, In Vitro Techniques, Research Support, Binding Sites/genetics, Serine Endopeptidases/metabolism, Serpins/genetics, Leukocytes, Recombinant Proteins/genetics, Humans, Amino Acid Sequence, Recombinant Proteins/pharmacology, Non-U.S. Gov't, Serpins, Serine Proteinase Inhibitors/pharmacology, Binding Sites, Serine Endopeptidases, Serine Proteinase Inhibitors/genetics, Leukocytes/enzymology, Recombinant Proteins, In Vitro, Serpins/pharmacology, Kinetics
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