Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective
Copyright policy )Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective
Interleukin-1 (IL-1) has been implicated in chronic and acute cerebral neuropathologies. IL-1 receptor antagonist (IL-1ra), a naturally occurring protein that binds to IL-1 receptors without inducing signal transduction, blocks several actions of IL-1. IL-1ra acts at the local level and it also circulates in the bloodstream. We now report evidence for a biological function of IL-1ra in the brain as an endogenous neuroprotective molecule. Cerebral expression of IL-1ra mRNA is induced rapidly by focal cerebral ischemia in rats, and inhibition of the action of IL-1ra, by passive immuno-neutralization, markedly enhances ischemic damage. To our knowledge this is the first report of an action of endogenous IL-1ra in the brain. Control of IL-1ra expression or action may therefore provide a useful therapeutic strategy to limit acute neurodegeneration.
- National Institutes of Health United States
- University of Manchester United Kingdom
- University of Manchester United Kingdom
- National Institute of Mental Health United States
- University of Manchester United Kingdom
Male, Sialoglycoproteins, Messenger, pharmacology: Interleukin-1, metabolism: Ischemic Attack, Antibodies, Rats, Sprague-Dawley, genetics: Sialoglycoproteins, antagonists & inhibitors: Receptors, immunology: Antibodies, Animals, RNA, Messenger, In Situ Hybridization, metabolism: Ischemic Attack, Transient, Transient, Brain, Receptors, Interleukin-1, antagonists & inhibitors: Receptors, Interleukin-1, Rats, metabolism: RNA, Messenger, Interleukin 1 Receptor Antagonist Protein, Neuroprotective Agents, Gene Expression Regulation, Ischemic Attack, Transient, metabolism: RNA, metabolism: Brain, Sprague-Dawley, Interleukin-1
Male, Sialoglycoproteins, Messenger, pharmacology: Interleukin-1, metabolism: Ischemic Attack, Antibodies, Rats, Sprague-Dawley, genetics: Sialoglycoproteins, antagonists & inhibitors: Receptors, immunology: Antibodies, Animals, RNA, Messenger, In Situ Hybridization, metabolism: Ischemic Attack, Transient, Transient, Brain, Receptors, Interleukin-1, antagonists & inhibitors: Receptors, Interleukin-1, Rats, metabolism: RNA, Messenger, Interleukin 1 Receptor Antagonist Protein, Neuroprotective Agents, Gene Expression Regulation, Ischemic Attack, Transient, metabolism: RNA, metabolism: Brain, Sprague-Dawley, Interleukin-1
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