Induction of CYP1A1 by GABA Receptor Ligands
Copyright policy )Induction of CYP1A1 by GABA Receptor Ligands
The induction of CYP1A1 is mediated via the aromatic hydrocarbon (Ah) receptor. Studies from our laboratory show CYP1A1 induction by picrotoxin and phenobarbital which prompted us to examine if other ligands of the gamma-aminobutyric acid (GABA) receptor could also induce CYP1A1. Here we report the nuclear translocation of the Ah receptor and its DNA binding activity to radiolabeled double-stranded synthetic xenobiotic response elements (XREs) in nuclear extracts, increased accumulation of CYP1A1 mRNA, and alterations in intracellular calcium concentrations in cells exposed to GABA receptor ligands.
- Astra Italy
- University of Bradford United Kingdom
- University of Gothenburg Sweden
Polychlorinated Dibenzodioxins, Amino Acids, Diamino, Biological Transport, Regulatory Sequences, Nucleic Acid, Ligands, Cell Compartmentation, GABA Antagonists, Liver, Receptors, Aryl Hydrocarbon, Receptors, GABA, Enzyme Induction, Oncorhynchus mykiss, Phenobarbital, Cytochrome P-450 CYP1A1, Animals, Calcium, RNA, Messenger, Cells, Cultured, gamma-Aminobutyric Acid, Protein Binding
Polychlorinated Dibenzodioxins, Amino Acids, Diamino, Biological Transport, Regulatory Sequences, Nucleic Acid, Ligands, Cell Compartmentation, GABA Antagonists, Liver, Receptors, Aryl Hydrocarbon, Receptors, GABA, Enzyme Induction, Oncorhynchus mykiss, Phenobarbital, Cytochrome P-450 CYP1A1, Animals, Calcium, RNA, Messenger, Cells, Cultured, gamma-Aminobutyric Acid, Protein Binding
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