Molecular Cloning of Human Hyaluronan Synthase
Copyright policy )Molecular Cloning of Human Hyaluronan Synthase
We report here the cDNA sequence of human hyaluronan synthase. The cDNA clone was isolated from a human fetal brain cDNA library by screening with a DNA probe generated from the coding sequence of murine hyaluronan synthase. It contains a 2107 bp cDNA insert which is composed of a 1629 bp open reading frame and a short segment of the 3'-untranslated region. Comparative analysis of the predicted coding region with the murine hyaluronan synthase sequence indicates 84.4% and 96.0% identity in nucleotide sequence and amino acid sequences, respectively. Northern analysis indicated that the gene was ubiquitously expressed in various human tissues.
DNA, Complementary, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Gene Expression, Glycosyltransferases, Membrane Proteins, Xenopus Proteins, Transferases, Humans, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Glucuronosyltransferase, Hyaluronan Synthases, Sequence Alignment, DNA Primers
DNA, Complementary, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Gene Expression, Glycosyltransferases, Membrane Proteins, Xenopus Proteins, Transferases, Humans, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Glucuronosyltransferase, Hyaluronan Synthases, Sequence Alignment, DNA Primers
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