Suppression of Translation Frameshift by Upstream Termination Codon

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1996 English Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 221, pages 602-608 (issn: 0006-291X,

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Authors: A, Honda; S, Nishimura;

doi: 10.1006/bbrc.1996.0642

pmid: 8630007

Suppression of Translation Frameshift by Upstream Termination Codon

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Abstract

Retroviruses employ translation frameshift for gene expression. Translation frameshift takes place at the slippery heptanucleotide sequence on mRNA. A downstream stem-loop structure (and a pseudoknot formed by the stem-loop) enhances the level of ribosomal frameshifting. Here, we describe that an upstream termination codon suppresses the ribosomal frameshifting, leading to reduction in the expression of downstream genes.

Related Organizations

Merck & Co.
United States

Keywords

Base Sequence, Recombinant Fusion Proteins, Molecular Sequence Data, Mammary Tumor Virus, Mouse, Protein Biosynthesis, DNA, Viral, Codon, Terminator, HIV-1, Amino Acid Sequence, RNA, Messenger, Frameshift Mutation, Luciferases

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