Isolation and Characterization ofCaenorhabditis elegansExtracellular Matrix
Copyright policy )Isolation and Characterization ofCaenorhabditis elegansExtracellular Matrix
The extracellular matrix (ECM) plays an important structural and functional role in multicellular organisms. Because of the similarities between C. elegans and vertebrate development, this nematode could serve as a simplified model to study the biology of the ECM. In this study, a method for extracting mammalian ECM was adapted for the extraction of C. elegans ECM. ECM components from C. elegans were found to be homologous to mammalian ECM by immunoblotting. It was also demonstrated that antibodies generated against C. elegans ECM stained basement membrane-like structures in C. elegans eggs, larvae, and adults.
- Illinois State University United States
- Langston University United States
Molecular Weight, Extracellular Matrix Proteins, Animals, Antibodies, Monoclonal, Cross Reactions, Caenorhabditis elegans, Basement Membrane, Extracellular Matrix
Molecular Weight, Extracellular Matrix Proteins, Animals, Antibodies, Monoclonal, Cross Reactions, Caenorhabditis elegans, Basement Membrane, Extracellular Matrix
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