Molecular Cloning of a Novel Basic Helix-Loop-Helix Protein from the Rat Brain
Copyright policy )Molecular Cloning of a Novel Basic Helix-Loop-Helix Protein from the Rat Brain
In the mammalian nervous system, several basic helix-loop-helix (bHLH) proteins have been identified that may play essential roles in neurogenesis or neural development. This paper describes a novel bHLH protein in rat brain, which has a bHLH domain highly homologous with that of MATH-2 and NeuroD. On the other hand, the amino-acid sequence of the other regions had little homology with those of the known proteins. This protein consists of 381 amino acids and was detected only in neural tissue, indicating that it has an important role specific to neuronal activities.
Basic Helix-Loop-Helix Proteins, Male, Mammals, Sequence Homology, Amino Acid, Helix-Loop-Helix Motifs, Molecular Sequence Data, Brain, Nerve Tissue Proteins, In Vitro Techniques, Hippocampus, Recombinant Proteins, Rats, Organ Specificity, Animals, Amino Acid Sequence, Cloning, Molecular, Conserved Sequence, In Situ Hybridization, Transcription Factors
Basic Helix-Loop-Helix Proteins, Male, Mammals, Sequence Homology, Amino Acid, Helix-Loop-Helix Motifs, Molecular Sequence Data, Brain, Nerve Tissue Proteins, In Vitro Techniques, Hippocampus, Recombinant Proteins, Rats, Organ Specificity, Animals, Amino Acid Sequence, Cloning, Molecular, Conserved Sequence, In Situ Hybridization, Transcription Factors
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