Different Expression of the Myotonin Protein Kinase Gene in Discrete Areas of Human Brain
Copyright policy )Different Expression of the Myotonin Protein Kinase Gene in Discrete Areas of Human Brain
We have examined the myotonin protein kinase (MT-PK) gene expression in different human brain areas. Four different spliced forms, comprising exons 13 and 14, were identified and characterized. One form (MYOT-A), lacking the entire exon 13, had not been detected in other studies and it is likely to be a brain-specific transcript. Different brain areas show a specific transcription pattern. These results suggest that MT-PK may have specialized functions in different areas of central nervous system. Alterations of this complex expression pattern could be responsible for the mental status impairment observed in myotonic dystrophy patients.
- University of Milan Italy
- University of Rome Tor Vergata Italy
- Catholic University of the Sacred Heart Italy
- Sapienza University of Rome Italy
- University of Brescia Italy
Base Sequence, Transcription, Genetic, Molecular Sequence Data, Brain, Gene Expression, Exons, Protein Serine-Threonine Kinases, Polymerase Chain Reaction, Myotonin-Protein Kinase, myotonin; brain; myotonic dystrophy; spliced forms, Alternative Splicing, Organ Specificity, Humans, Protein Kinases, DNA Primers
Base Sequence, Transcription, Genetic, Molecular Sequence Data, Brain, Gene Expression, Exons, Protein Serine-Threonine Kinases, Polymerase Chain Reaction, Myotonin-Protein Kinase, myotonin; brain; myotonic dystrophy; spliced forms, Alternative Splicing, Organ Specificity, Humans, Protein Kinases, DNA Primers
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