Eye CNG Channel Is Modulated by Nicotine
Copyright policy )Eye CNG Channel Is Modulated by Nicotine
The cyclic-nucleotide gated channel (CNG channel) of the rod outer segment of the retina (ROS) has its closed conformation stabilized by nicotine. Calcium and cGMP influence the Ki of the channel current to nicotine. Calcium lowers the Ki and cGMP increases it, giving a range of Ki between 10(-11) and 10(-8) M.
- Harvard University United States
Nicotine, Dose-Response Relationship, Drug, Protein Conformation, Cyclic Nucleotide-Gated Cation Channels, Rod Cell Outer Segment, Models, Biological, Ion Channels, Retina, Membrane Potentials, Kinetics, Animals, Calcium, Rabbits, Eye Proteins, Cyclic GMP, Ion Channel Gating, Mathematics
Nicotine, Dose-Response Relationship, Drug, Protein Conformation, Cyclic Nucleotide-Gated Cation Channels, Rod Cell Outer Segment, Models, Biological, Ion Channels, Retina, Membrane Potentials, Kinetics, Animals, Calcium, Rabbits, Eye Proteins, Cyclic GMP, Ion Channel Gating, Mathematics
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