Genomic Organization of a Mouse Type I Activin Receptor
Copyright policy )Genomic Organization of a Mouse Type I Activin Receptor
We have characterized the genomic organization of a mouse type I activin receptor. Using the mouse tsk7L cDNA, 4 overlapping lambda clones containing the activin receptor IA (ActRIA) gene were isolated from a mouse 129 Sv genomic library. The mouse ActRIA gene is encoded by 10 exons and spans approximately 40 kb. The size of the introns was determined and the intron/exon boundaries were sequenced. Primer extension analysis of the 5' non-translated region using RNA from different organs or tissues revealed a strong transcription start site 68 nucleotides upstream of the ATG. Knowledge of the structure of the ActRIA gene is essential for the production of ActRIA deficient mice by homologous recombination.
Genomic Library, Base Sequence, Activin Receptors, Molecular Sequence Data, Restriction Mapping, Brain, DNA, Exons, Protein Serine-Threonine Kinases, Introns, Cell Line, Mice, Open Reading Frames, Organ Specificity, Protein Biosynthesis, Animals, Humans, Receptors, Growth Factor, Cloning, Molecular, DNA Primers
Genomic Library, Base Sequence, Activin Receptors, Molecular Sequence Data, Restriction Mapping, Brain, DNA, Exons, Protein Serine-Threonine Kinases, Introns, Cell Line, Mice, Open Reading Frames, Organ Specificity, Protein Biosynthesis, Animals, Humans, Receptors, Growth Factor, Cloning, Molecular, DNA Primers
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