Regulation of FGF-4 Enhancer Activity by Transcription Factor NF-Y
Copyright policy )Regulation of FGF-4 Enhancer Activity by Transcription Factor NF-Y
Regulation of FGF-4 gene expression is controlled both by elements in the promoter and by an enhancer domain located in the untranslated region of the third exon. We have determined that transcription factor NF-Y binds to the FGF-4 promoter. We further show by mutational analysis that binding of NF-Y is essential for FGF-4 enhancer activity but has minimal effect on activity of the FGF-4 promoter alone.
- The Ohio State University United States
Base Sequence, Molecular Sequence Data, Fibroblast Growth Factor 4, Methylation, Polymerase Chain Reaction, Cell Line, DNA-Binding Proteins, Fibroblast Growth Factors, Gene Expression Regulation, Neoplastic, Mice, Enhancer Elements, Genetic, Carcinoma, Embryonal, CCAAT-Enhancer-Binding Proteins, Mutagenesis, Site-Directed, Animals, Cloning, Molecular, Luciferases, Promoter Regions, Genetic, DNA Primers, Plasmids
Base Sequence, Molecular Sequence Data, Fibroblast Growth Factor 4, Methylation, Polymerase Chain Reaction, Cell Line, DNA-Binding Proteins, Fibroblast Growth Factors, Gene Expression Regulation, Neoplastic, Mice, Enhancer Elements, Genetic, Carcinoma, Embryonal, CCAAT-Enhancer-Binding Proteins, Mutagenesis, Site-Directed, Animals, Cloning, Molecular, Luciferases, Promoter Regions, Genetic, DNA Primers, Plasmids
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