The enhancement of UVB on the surface of the earth due to stratospheric ozone depletion may increase the risk of photochemically induced cataract. In this study, changes in the content of certain biological parameters were used as a marker to study ocular toxicity. A significant enhancement in the level of H2O2, LP and Pi, along with the depletion of GSH (antioxidant-defence system) in serum, aqueous humor and lens of albino mice exposed to UVB was observed. The level of Ca++ increased in serum and aqueous humor but decreased considerably in the lens due to increase in UVB exposure. These observations provide further clues to support the involvement of oxidative stress and Ca++ in the events leading to the formation of cataract.