Cytosolic Localization of β3-Subunit of Heterotrimeric GTP Binding Protein in Rat Hearts
Copyright policy )Cytosolic Localization of β3-Subunit of Heterotrimeric GTP Binding Protein in Rat Hearts
The expression of three different subtypes of GTP binding protein beta-subunits (beta 1, beta 2 and beta 3) was examined in rat hearts at both mRNA and protein levels. Among three subtypes, beta 3 mRNA was more abundant in ventricles while beta 1 and beta 2 mRNAs were expressed ubiquitously among ventricles, atria and aortas. The immunodetectable beta 1- and beta 3-proteins were predominantly found in the cytosolic fraction of rat ventricles. In this study, we demonstrate ventricle-specific expression of beta 3-subunit and localization of G protein beta 3-subunit in the cytosol of rat hearts. This unusual cytosolic localization of G protein beta 3-subunit might indicate subtype-specific function of G protein beta (gamma)-subunits in rat hearts.
- Hokkaido Bunkyo University Japan
- Hokkaido University Japan
Male, Macromolecular Substances, Heart Ventricles, Myocardium, Blotting, Western, Brain, Gene Expression, Blotting, Northern, Rats, Inbred WKY, Retina, Rats, Cytosol, GTP-Binding Proteins, Animals, Cattle, Heart Atria, RNA, Messenger, Aorta
Male, Macromolecular Substances, Heart Ventricles, Myocardium, Blotting, Western, Brain, Gene Expression, Blotting, Northern, Rats, Inbred WKY, Retina, Rats, Cytosol, GTP-Binding Proteins, Animals, Cattle, Heart Atria, RNA, Messenger, Aorta
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