Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 05 Oct 2021 English Publisher:WileyJournal:WIREs Mechanisms of Disease, volume 14 (issn: 2692-9368, eissn: 2692-9368,

Copyright policy )

Authors: Chao‐Yue Cui; Qiwei Chen; Qian He; Chong Chen; Rong‐Min Zhang; Youjun Feng; Jian Sun;

doi: 10.1002/wsbm.1538

pmid: 35023325

Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family

- Summary
- Subjects
- Metrics

Abstract

AbstractTetracycline and its derivative tigecycline are clinical options against Gram‐negative bacterial infections. The emergence of mobile Tet(X) enzymes that destruct tetracycline‐type antibiotics is posing a big challenge to antibacterial therapy and food/environmental securities. Here, we present an update on a growing number of Tet(X) variants. We describe structure and action of Tet(X) enzyme, and discuss the evolutional origin. In addition, potential Tet(X) inhibitors are given. This mini‐review might benefit better understanding of Tet(X)‐mediated tigecycline resistance.This article is categorized under: Infectious Diseases > Genetics/Genomics/Epigenetics Infectious Diseases > Environmental Factors Infectious Diseases > Molecular and Cellular Physiology

Related Organizations

Chinese Academy of Agricultural Sciences
China (People's Republic of)
Lanzhou Veterinary Research Institute
China (People's Republic of)
Zhejiang Ocean University
China (People's Republic of)
Yangzhou University
China (People's Republic of)
South China Agricultural University
China (People's Republic of)

View all View all

Keywords

Tetracycline Resistance, Microbial Sensitivity Tests, Tetracycline, Tigecycline, Anti-Bacterial Agents

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	13
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%