Transfer RNA‐derived fragments: origins, processing, and functions
Copyright policy )Transfer RNA‐derived fragments: origins, processing, and functions
AbstractDeep sequencing approaches have revealed multiple types of small RNAs with known and unknown functions. In this review we focus on a recently identified group of small RNAs that are derived from transfer RNAs (tRNAs), tRNA fragments (tRFs). We review the mechanism of their processing and their functions in mammalian cells, and highlight points of possible cross‐talk between tRFs and the canonical small RNA pathway characterized by small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi‐interacting RNAs (piRNAs). We also propose a nomenclature that is based on their processing characteristics. WIREs RNA 2011 2 853–862 DOI: 10.1002/wrna.96This article is categorized under: RNA Processing > tRNA Processing Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs
- University of Dundee United Kingdom
- University of Technology Russian Federation
- University of Technology Sydney Australia
MicroRNAs, RNA, Transfer, Argonaute Proteins, Animals, Humans, RNA, Small Untranslated, RNA Processing, Post-Transcriptional, RNA, Small Interfering, Models, Biological
MicroRNAs, RNA, Transfer, Argonaute Proteins, Animals, Humans, RNA, Small Untranslated, RNA Processing, Post-Transcriptional, RNA, Small Interfering, Models, Biological
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