RNA nucleotide methylation
Copyright policy )RNA nucleotide methylation
AbstractMethylation of RNA occurs at a variety of atoms, nucleotides, sequences and tertiary structures. Strongly related to other posttranscriptional modifications, methylation of different RNA species includes tRNA, rRNA, mRNA, tmRNA, snRNA, snoRNA, miRNA, and viral RNA. Different catalytic strategies are employed for RNA methylation by a variety of RNA‐methyltransferases which fall into four superfamilies. This review outlines the different functions of methyl groups in RNA, including biophysical, biochemical and metabolic stabilization of RNA, quality control, resistance to antibiotics, mRNA reading frame maintenance, deciphering of normal and altered genetic code, selenocysteine incorporation, tRNA aminoacylation, ribotoxins, splicing, intracellular trafficking, immune response, and others. Connections to other fields including gene regulation, DNA repair, stress response, and possibly histone acetylation and exocytosis are pointed out. WIREs RNA 2011 2 611–631 DOI: 10.1002/wrna.79This article is categorized under: RNA Processing > RNA Editing and Modification
- University of Lorraine France
- UNIVERSITE DE NANCY II France
- Johannes Gutenberg University of Mainz Germany
Models, Molecular, tRNA Methyltransferases, Binding Sites, RNA, Archaeal, Methylation, RNA, Bacterial, RNA, Transfer, RNA, Ribosomal, Protein Biosynthesis, Drug Resistance, Bacterial, Biocatalysis, Nucleic Acid Conformation, RNA, RNA, Viral, RNA Processing, Post-Transcriptional
Models, Molecular, tRNA Methyltransferases, Binding Sites, RNA, Archaeal, Methylation, RNA, Bacterial, RNA, Transfer, RNA, Ribosomal, Protein Biosynthesis, Drug Resistance, Bacterial, Biocatalysis, Nucleic Acid Conformation, RNA, RNA, Viral, RNA Processing, Post-Transcriptional
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