Eukaryotic 5S rRNA biogenesis
Copyright policy )Eukaryotic 5S rRNA biogenesis
AbstractThe ribosome is a large complex containing both protein and RNA which must be assembled in a precise manner to allow proper functioning in the critical role of protein synthesis. 5S rRNA is the smallest of the RNA components of the ribosome, and although it has been studied for decades, we still do not have a clear understanding of its function within the complex ribosome machine. It is the only RNA species that binds ribosomal proteins prior to its assembly into the ribosome. Its transport into the nucleolus requires this interaction. Here we present an overview of some of the key findings concerning the structure and function of 5S rRNA and how its association with specific proteins impacts its localization and function.WIREs RNA2011 2 523–533 DOI: 10.1002/wrna.74This article is categorized under:Translation > Translation MechanismsRNA Processing > RNA Editing and ModificationRNA Processing > tRNA ProcessingRNA in Disease and Development > RNA in Disease
- University at Buffalo, State University of New York United States
- State University of New York at Potsdam United States
Models, Molecular, Ribosomal Proteins, Cytoplasm, Base Sequence, RNA, Ribosomal, 5S, RNA-Binding Proteins, Models, Biological, Mitochondria, Transcription Factor TFIIIA, Animals, Humans, Nucleic Acid Conformation, RNA Processing, Post-Transcriptional, Ribosomes
Models, Molecular, Ribosomal Proteins, Cytoplasm, Base Sequence, RNA, Ribosomal, 5S, RNA-Binding Proteins, Models, Biological, Mitochondria, Transcription Factor TFIIIA, Animals, Humans, Nucleic Acid Conformation, RNA Processing, Post-Transcriptional, Ribosomes
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