Abstract This report describes a case of severe, sudden‐onset, widespread vasculitis affecting a dog concurrently infected by E hrlichia canis and Babesia canis . Following diagnostic investigations, the dog was suspected of an immune‐mediated vasculitis, possibly triggered by E. canis, B. canis or their combination. The lesions completely resolved after a multimodal treatment protocol including prednisolone, ciclosporin, pentoxifylline, doxycycline and imidocarb dipropionate.