Abstract An 8‐year‐old, spayed, female shar‐pei with an earlier clinical diagnosis of shar‐pei autoinflammatory disease presented with fever and plaque‐nodular ulcerative dermatitis. Dermatopathological examination was compatible with diffuse, non‐septal, neutrophilic panniculitis and leukocytoclastic vasculitis, and bacterial culture was negative. Good response to prednisone treatment was seen. Based on this case, cutaneous sterile neutrophilic panniculitis and leukocytoclastic vasculitis may be associated with shar‐pei autoinflammatory disease.