ABSTRACT Ancylostoma caninum , a zoonotic hookworm species, significantly affects the global health of companion animals, humans and wildlife populations. This parasitic infection is prevalent in various environments, particularly in regions with warm climates, and affects a wide range of canids, including dogs, where it is most commonly found. A. caninum is a major concern not only due to its zoonotic potential but also because of its growing resistance to anthelmintic treatments. The development of resistance in parasitic species is primarily driven by genetic mutations that allow the parasite to survive treatment with commonly used drugs and presents a serious challenge to parasite control efforts. This review explores the biology and epidemiology of A. caninum , focusing on the mechanisms and prevalence of anthelmintic resistance. By reviewing worldwide studies, this paper highlights the prevalence of resistance across different anthelmintic classes and its implications for veterinary and public health. The findings emphasize the need for better management strategies and innovative solutions to address this growing problem.