
pmid: 4737490
AbstractThe teratogenic effects of subcutaneous injections of cadmium in CD rats were investigated. Injections of 4–12 mg/kg CdCl2 on 4 consecutive days beginning on days 13–16 of gestation resulted in a dose‐related rise in the fetal death rate, decrease in fetal weight, arid increase in the rate of anomalies. The anomalies included micrognathia, cleft palate, clubfoot, and small lungs. The lung/body weight ratios were significantly reduced in fetuses of animals injected with 8 mg/kg CdCl2 on days 14–17 of gestation. The data indicate that this was a specific retardation and not merely a reflection of differential organ growth rates and overall fetal growth retardation.
Dose-Response Relationship, Drug, Injections, Subcutaneous, Micrognathism, Abnormalities, Drug-Induced, Gestational Age, Organ Size, Rats, Cleft Palate, Clubfoot, Chlorides, Pregnancy, Animals, Female, Fetal Death, Lung, Maternal-Fetal Exchange, Cadmium
Dose-Response Relationship, Drug, Injections, Subcutaneous, Micrognathism, Abnormalities, Drug-Induced, Gestational Age, Organ Size, Rats, Cleft Palate, Clubfoot, Chlorides, Pregnancy, Animals, Female, Fetal Death, Lung, Maternal-Fetal Exchange, Cadmium
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