SummaryThe relatively large number of structural elements and the variety of design code requirements complicate the design process of tall buildings. This process is exacerbated when the target is to obtain the seismic code‐compliant optimal design with minimum weight. The present paper aims at providing a practical methodology for the optimal design of steel tall building structures considering the constraints imposed by typical building codes. The applicability of the proposed approach is demonstrated through the determination of the optimal seismic design for 20‐, 40‐, and 60‐story buildings with a framed tube as well as a tube‐in‐tube system. Such a design gives rise to a basis for the fair comparison of the behavior of the framed tube with that of the tube‐in‐tube system under applied loads. The optimal weight of the buildings with the tube‐in‐tube system turns out to be slightly less than that of the buildings with the conventional framed‐tube system.