Effects of adrenalectomy on CART expression in the rat arcuate nucleus
Copyright policy )Effects of adrenalectomy on CART expression in the rat arcuate nucleus
AbstractIn order to test for glucocorticoid regulation of CART in the arcuate nucleus, adrenalectomies (ADX) and hormone replacements (HRs) were carried out in groups of rats. CART mRNA levels were determined by in situ hybridization and CART peptide levels by immunocytochemistry. ADX caused a lowering of CART mRNA and peptides levels in the arcuate and this was reversed by HR. These results indicate a glucocorticoid regulation of CART in the arcuate. The regulation could be direct through an action of glucocorticoid receptors or indirectly through ADX‐induced changes in leptin levels. These findings suggest a role for CART in the stress response. Synapse 50:14–19, 2003. © 2003 Wiley‐Liss, Inc.
- Emory National Primate Research Center United States
- Ege University Turkey
- Yerkes National Primate Research Center United States
Arcuate Nucleus of Hypothalamus, adrenalectomy, Down-Regulation, Adrenalectomy, Nerve Tissue Proteins, CART peptide, leptin, Immunohistochemistry, Rats, stress, Receptors, Glucocorticoid, Adrenal Cortex, arcuate nucleus, Animals, RNA, Messenger, Cocaine- and Amphetamine-Regulated Transcript Protein, Glucocorticoids
Arcuate Nucleus of Hypothalamus, adrenalectomy, Down-Regulation, Adrenalectomy, Nerve Tissue Proteins, CART peptide, leptin, Immunohistochemistry, Rats, stress, Receptors, Glucocorticoid, Adrenal Cortex, arcuate nucleus, Animals, RNA, Messenger, Cocaine- and Amphetamine-Regulated Transcript Protein, Glucocorticoids
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